Division of Hematology/Oncology
Department of Pediatrics
Duke University School of Medicine
Chapel Hill, NC
Dr. Becher received his medical degree from Johns Hopkins University in Baltimore, MD and residency in Pediatrics from Children’s National Medical Center in Washington, DC. He completed his fellowship training in Pediatric Hematology/Oncology and Pediatric Neuro-Oncology at Memorial Sloan-Kettering Cancer Center in New York, NY where his research focused on gliomas in children. Dr. Becher joined Duke University in 2010.
Dr. Becher’s laboratory interests are to apply genetic mouse models of pediatric brain tumors to prioritize the translation of novel agents into clinical trials. In particular, his laboratory is using a genetic mouse model of Diffuse Intrinsic Pontine Gliomas (DIPG) to determine therapeutic targets, unravel ways to bypass the blood-brain-barrier, and investigate region-specific differences between gliomagenesis in the brainstem and the cortex. His laboratory is also developing improved genetic mouse models of DIPG and applying them as preclinical tools to help prioritize the translation of novel agents into clinical trials for DIPG. Moreover, his lab is interested in investigating mechanisms of resistance towards novel targeted agents.